KMID : 0360319940260060885
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Journal of Korean Cancer Research Association 1994 Volume.26 No. 6 p.885 ~ p.891
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Correlation of PLC-rl Expression and DNA Ploidy Pattern in Hepatocellular Carcinomas
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Abstract
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Phospholipase C isozymes (PLCs) play a role in ligand-mediated signal transduction for cellular activity such as proliferation and differentation. However, their biological significance of in carcinogenesis or tumor progression is not fully
estabilished, although PLC-¥ã1 is known to be related to the cell growth or the oncogene.
We examined the relative content of PLC-¥ã1 in human hepatocellular carcinoma (HCC) and the adjacent non tumorous liver tissue, by immunoperoxidase staining of paraffin embedded sections.
Among 32 cases, 25 demonstrated a significant decrease of PLC-¥ã1 content in comparison to the adjacent nontumorous tissue. Seven cases revealed no remarkable change in PLC-¥ã1 expression. There was no HCC expressing higher level of PLC-¥ã1.
We also performed image cytometric studies to evaluate the relationship between the DNA ploidy pattern and the PLC-¥ã1 content. Interestingly, the tumors showing a decreased PLC-¥ã1 expression, were mostly diploid and tetraploid (except 3 cases)
in
contrast to those tumors showing no change in PLC-¥ã1 content which were exclusively aneuploid.
The results suggest that PI C¥ã1 expression is closely related to DNA ploidy of the tumor, and that there may be two different mechanisms of hepatocarcinogenesis: one is related to PLC-¥ã1 associated signal trasduction system, and the other is
independent of PLC-¥ã1.
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KEYWORD
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